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Abstract
The venom of cone snails is composed highly conopeptides that target a variety of ion channels and receptors on the nerve system. The venom of Conus genus represents unexploited resources of potential pharmaceutical compounds. The venom of Conus marmoreus collected in Nha Trang Bay was separated by reversed–phase high-performance liquid chromatography (RP-HPLC), and fractions were analyzed using matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF-MS). The results of RP-HPLC showed that the crude venom consists mainly hydrophobic peptides. Using MALDI-TOF MS analysis of crude venom yielded a total of 7543 distinct masses. Besides, there were 1751 compounds found in crude venom of Conus marmoreus in Nha Trang Bay. Among them, we determined the molecular weights of 39 peptides of C. marmoreus venom in Vietnam compared to the total 92 peptides of C. marmoreus previously identified.
Key words: Conus marmoreus, Peptide, Venom, LC MALDI-TOF MS.